Efficacy and safety of intravaginal gas ozone therapy in the treatment of bacterial vaginosis

Aims: The aim of this study is to share our experiences and results with our intravaginal gas ozone technique in the treatment of bacterial vaginosis (BV) by retrospective data analysis. Methods: Salutem plus brand medical ozone device, 60 gamma 200 cc gas ozone was administered intravaginally through 50 cc syringes with the help of a nasogastric catheter to 102 patients diagnosed with BV using Amsel criteria. Patients whose hemogram parameters were checked before and after the procedure were called for 1st, 3rd, 6th, 9th and 12th month clinical controls in terms of recurrence, and the examination findings and digital data of these patients were analyzed retrospectively in terms of treatment, complications and recurrence. Results: No life-threatening complications were encountered. Minor adverse effects were observed and resolved spontaneously in a short time without the need for any treatment. Recurrence rates were observed to be lower than in classical regimen treatments. Additionally, no more than 2 recurrences were observed during 1-year follow-up. Conclusion: Our study is the first example of the literature in terms of evaluation of treatment, recurrence and complications of intravaginal gas ozone therapy in the treatment of bacterial vaginosis. These finding suggest that intravaginal gas ozone therapy, which is considered a safe form of treatment, will become more widespread in the future and the number and frequency of its application will increase even more. Further investigation with a larger number of patients should be conducted to confirm our data.