Diabetes mellitus and hemostasis. Intrigue of relationships. Part 1. Endothelial dysfunction

This literature review is the first in a series of articles devoted to the mutual influence of diabetes mellitus (DM) and hemostatic disorders associated with endothelial dysfunction (ED), changes in platelet activity, plasma-coagulation link of hemostasis, activity of natural anticoagulants and fibrinolysis. The main mechanisms of development of ED, the possibilities of its detection not only in scientific research, but also in routine clinical practice are analyzed. The main principles of both non-drug and drug correction of ED are also given. Emphasis is placed on the possibility of using for this purpose drugs with and without a hypoglycemic effect. An opinion is expressed about the presence of a reverse effect of ED on the imbalance of carbohydrate metabolism, which, in the opinion of the authors, can significantly expand the understanding of the role of these disorders not only in the development of complications, but also in the pathogenesis of diabetes mellitus itself.