Early and long-term results of transplantation treatment of patients with stage 4–5 chronic kidney disease in the outcome of type 1 diabetes mellitus

BACKGROUND . Patients with diabetic chronic kidney disease (CKD) stage 5 comprise the most severe group of dialysis patients. The half-life of this group from the moment of starting renal replacement therapy is between 3.5 and 5 years. Transplantation treatment is the preferred method for treating this category of patients. AIM. The objective of the study was to methodically examine the preliminary and long-term outcomes of transplantation treatment in patients diagnosed with type 1 diabetes mellitus (DM1) and stage 4–5 chronic kidney disease. MATERIALS AND METHODS . From 2007 to 2023, the kidney and pancreas transplant unit performed 146 kidney transplantations and 84 simultaneous pancreas-kidney transplantations (SPKT) in patients with CKD as an outcome of DM1. RESULTS . During the entire follow-up period, the overall survival rate for kidney transplant patients was 67.1% (n=98) and 59.6% (n=87) for renal grafts; among SPKT patients, these rates were 76.2% (n=64) and 70.2% (n=59), respectively, with a pancreas graft survival rate of 64.3% (n=54). CONCLUSION. The results of transplant treatment of patients with DM1 and stage 4-5 CKD are presented in this article.