Effects of Different Exercise Protocols on the Oxidative Balance in the Cerebellum of Rodents: a Systematic Review

Abstract Physical exercise promotes numerous benefits in health promotion and disease prevention, that includes protection against oxidative damage in the cerebellum that has been associated with neurodegenerative diseases. However, exercise can be a potential therapeutic agent, but its response depends on individual and exercise factors such as type, intensity, and frequency of exercise. The aim of the review was to evaluate the effects of different exercise protocols on oxidative balance in the cerebellum. A literature search was performed using multiple literature databases (MEDLINE (PubMed), Web of Science, Scopus and Embase) in July 2024. In total, 329 articles were found and 11 studies that met the eligibility criteria were included in the review. The protocol was registered in PROSPERO (CRD42023411207), and we followed PRISMA (Preferred Reporting Items for Systematic Reviews) Checklist. The results found show that in most studies, exercise was able to modulate oxidative stress parameters, however, due to the differences in the evaluated parameters and methodological differences, it was not possible to highlight the best exercise protocol to improve oxidative balance in the cerebellum. Despite that, the review points to new perspectives on exercise strategies for prevention or treatment of diseases that are related to cerebellar oxidative stress that can potentially help health promotion.