Electrochemical quantitation of meloxicam using reduced graphene oxide‐based sensing platform

Abstract Meloxicam (MEL) is a nonsteroidal anti‐inflammatory medication with antipyretic, anti‐inflammatory, and analgesic properties. Establishing a sensitive and reliable method to monitor MEL in pharmaceutical formulations is critical to ensure dosing accuracy and guarantee therapeutic efficacy. Herein, a simple electrochemical method was developed for the determination of MEL levels using a TiO 2 ‐Ag‐reduced graphene oxide (TiO 2 ‐Ag‐rGO) nanocomposite‐modified electrode in pH 3.0 Britton–Robinson (BR) buffer via the differential pulse voltammetric (DPV) technique. The prepared TiO 2 ‐Ag‐rGO nanocomposite was characterized by scanning electron microscopy (SEM), X‐ray diffractometer (XRD), and X‐ray photoelectron spectroscopy (XPS) to analyze its morphology, structure, and composition. It was then coated onto a glassy carbon electrode (GCE) surface to construct the TiO 2 ‐Ag‐rGO/GCE. On this modified electrode, the oxidation peak current of MEL centered at 0.65 V showed a notable improvement and was linear with MEL concentrations ranging from 0.5 to 150 μM using optimal parameters. The detection limit calculated for MEL was 15.2 nM (S/N = 3). Application of the method for the assay of MEL in the commercially available tablets form, acceptable deviation from the stated concentration and satisfactory accuracy were obtained.