Mechanisms of Different Intestinal Flora in Gastric Cancer

As one of the global cancers, gastric cancer is characterized by “double-high” morbidity and mortality, which seriously jeopardizes human health. Therefore, early diagnosis of gastric cancer or better treatments are warranted to improve this situation. Although Helicobacter pylori has been recognized as the strongest oncogenic factor in gastric carcinogenesis, with the development of gene sequencing technology, researchers have found that the enrichment and diversity of intestinal flora are also involved in the whole process of gastric cancer development, progression, treatment, and prognosis. In this paper, we will review the mechanisms of different intestinal flora in gastric cancer from various aspects, which will help to further explore its clinical value and provide new directions for the early diagnosis and treatment of gastric cancer in the future.