Childhood trauma and subclinical hypomania in early adulthood: A genetically informative study
The associations between childhood trauma and subclinical hypomania and high-risk for BD were partially attributed to shared genetic factors. These associations were also moderated by MDD-PGS. Gene-environment correlations were detected between childhood trauma and polygenic vulnerability to psychiatric and neurodevelopmental conditions. The etiology of hypomania and BD is likely the result of a confluence of genetic and environmental factors, and research in this area should account for potential genetic confounding.
Authors
- Mark J. Taylor (ORCID: https://orcid.org/0000-0001-5161-4182)
- Erin G Lawrence
- Georgina M. Hosang (ORCID: https://orcid.org/0000-0002-4683-3636)
- Angelica Ronald (ORCID: https://orcid.org/0000-0002-9576-2176)
- Laura Havers (ORCID: https://orcid.org/0000-0003-2529-4669)
- Irene González-Calvo (ORCID: https://orcid.org/0000-0001-8058-5894)
Institutions
- Queen Mary University of London (GB)
- Karolinska Institutet (SE)
- University of Surrey (GB)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10117
- Primary Topic
- Child and Adolescent Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- Economic and Social Research Council