Ischaemic preconditioning regulates cardiac transcriptome via DNA methylation conferring cardio-protection from ischaemic reperfusion injury
IPC re-programmes the cardiac transcriptome through dynamic DNA methylation, enhancing myocardial resilience while increasing stunning as an adaptive mechanism to limit necrosis.
Authors
- Björn Redfors (ORCID: https://orcid.org/0000-0002-4155-4451)
- Karin Jandeleit‐Dahm (ORCID: https://orcid.org/0000-0003-2192-5822)
- Yalda Kakaei
- Aaron Shekka Espinosa (ORCID: https://orcid.org/0000-0003-4336-5045)
- Scott Maxwell (ORCID: https://orcid.org/0000-0002-7801-0714)
- Ahmed Elmahdy (ORCID: https://orcid.org/0009-0009-6980-1504)
- Shafaat Hussain (ORCID: https://orcid.org/0000-0001-8008-7262)
- Abdul Waheed Khan (ORCID: https://orcid.org/0000-0001-6626-6897)
- Elmir Ömerovic (ORCID: https://orcid.org/0000-0002-3875-8621)
- Abhishek Jha (ORCID: https://orcid.org/0000-0001-9161-0450)
- Misbah Aziz
Institutions
- Diabetes Australia (AU)
- Sahlgrenska University Hospital (SE)
- Wallenberg Wood Science Center (SE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Heinrich Heine University Düsseldorf (DE)
- Monash University (AU)
- University of Gothenburg (SE)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ehjopen/oeaf124
- Citations
- 3
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- European Commission
- National Heart Foundation of Australia
- Hjärt-Lungfonden
- Vetenskapsrådet
- Medical Research Council
- National Health and Medical Research Council