The Gut as a Source of Infection for Fungal Pathogens: Increased Fecal <i>Candida albicans</i> Precedes Onset of <i>Candida</i> Late-Onset Sepsis in Very Preterm Infants
Increased fecal C albicans preceded Candida LOS onset, implicating the preterm gut as a potential source of infection. Reduced bacterial yields and diversity suggest ecological alterations that may facilitate Candida pathogenicity in the preterm gut. These findings support further research into gut-derived Candida LOS and the potential for microbiota-targeted prevention strategies.
Authors
- Isabelle van Thiel (ORCID: https://orcid.org/0000-0002-8298-9048)
- Wouter J. de Jonge (ORCID: https://orcid.org/0000-0002-3241-1547)
- Irini Kreulen (ORCID: https://orcid.org/0000-0002-6640-8055)
- Nina M. Frerichs (ORCID: https://orcid.org/0000-0002-3568-863X)
- Xanthe Verdoes
- Christian V. Hulzebos (ORCID: https://orcid.org/0000-0002-8159-7501)
- Iris Admiraal (ORCID: https://orcid.org/0000-0003-3335-4924)
- Veerle Cossey
- Tim G. J. de Meij (ORCID: https://orcid.org/0000-0002-7556-5896)
- Hendrik J. Niemarkt (ORCID: https://orcid.org/0000-0002-0844-7208)
- Chris H.P. van den Akker (ORCID: https://orcid.org/0000-0002-5494-730X)
- Mark Davids (ORCID: https://orcid.org/0000-0003-3081-9124)
- Marijn J. Vermeulen (ORCID: https://orcid.org/0000-0001-9686-8186)
- Willem P. de Boode (ORCID: https://orcid.org/0000-0003-3194-7005)
- Mirjam M. van Weissenbruch (ORCID: https://orcid.org/0000-0002-8086-9552)
- Marlou M A Kouwenberg-Raets
- Rimke R. de Kroon (ORCID: https://orcid.org/0000-0002-7971-3120)
- Daniel C Vijlbrief
- Aranka E van Wesemael
Institutions
- Radboud University Nijmegen (NL)
- University Hospital Bonn (DE)
- Academic Center for Dentistry Amsterdam (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam Institute for Global Health and Development (NL)
- Máxima Medisch Centrum (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Eindhoven University of Technology (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/infdis/jiaf524
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00