Spatially Discontinuous Mutation Topographies in Ductal Carcinoma <i>In Situ</i> Reveal Noncompetitive Growth Dynamics
The spatial mutation landscape in ductal carcinoma in situ supports a noncompetitive growth model mirroring normal branching morphogenesis, which has implications for managing low-risk patients and for cancers in other branching organs. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
Authors
- Joseph Geradts (ORCID: https://orcid.org/0009-0002-3817-8499)
- Diego Mallo (ORCID: https://orcid.org/0000-0002-9046-8859)
- Marc D. Ryser (ORCID: https://orcid.org/0000-0002-4990-0849)
- Lars J. Grimm (ORCID: https://orcid.org/0000-0002-3865-3352)
- E. Shelley Hwang (ORCID: https://orcid.org/0000-0002-8571-1148)
- Kevin A. Murgas (ORCID: https://orcid.org/0000-0001-8634-2893)
- Darryl Shibata (ORCID: https://orcid.org/0000-0002-4567-1639)
- Jeffrey R. Marks (ORCID: https://orcid.org/0000-0002-2054-5468)
- Lorraine King (ORCID: https://orcid.org/0009-0004-4617-7458)
- Robert B. West (ORCID: https://orcid.org/0000-0002-8330-8283)
- Inmaculada C. Sorribes (ORCID: https://orcid.org/0000-0001-8348-3746)
- Shannon T. Holloway (ORCID: https://orcid.org/0009-0005-6757-7503)
- Ethan Wu (ORCID: https://orcid.org/0009-0008-9700-3940)
- Carlo C. Maley (ORCID: https://orcid.org/0000-0002-0745-7076)
- Allison Hall (ORCID: https://orcid.org/0000-0003-3413-603X)
- Donald L. Weaver (ORCID: https://orcid.org/0009-0003-9946-9369)
- Matthew A. Greenwald (ORCID: https://orcid.org/0009-0002-3366-5079)
- Daniel Monyak (ORCID: https://orcid.org/0009-0000-5811-4287)
Institutions
- University of Vermont (US)
- University of Southern California (US)
- City Of Hope National Medical Center (US)
- Duke University (US)
- Palo Alto University (US)
- East Carolina University (US)
- Duke Medical Center (US)
- Arizona State University (US)
- Stony Brook University (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4415
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- U.S. Department of Defense
- Breast Cancer Research Foundation
- Arizona Biomedical Research Commission
- National Institutes of Health
- Congressionally Directed Medical Research Programs