A human pan-disease blood atlas of the circulating proteome
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
Authors
- Martin Höglund (ORCID: https://orcid.org/0000-0003-2468-0226)
- Helena Janols (ORCID: https://orcid.org/0000-0002-3857-163X)
- Kristoffer Strålin (ORCID: https://orcid.org/0000-0002-8801-3169)
- Søren Brage (ORCID: https://orcid.org/0000-0002-1265-7355)
- Fredrik Pontén (ORCID: https://orcid.org/0000-0003-0703-3940)
- Joy Roy (ORCID: https://orcid.org/0000-0002-5645-1260)
- Jan Mulder (ORCID: https://orcid.org/0000-0003-3717-5018)
- Fredrik Edfors (ORCID: https://orcid.org/0000-0002-0017-7987)
- Levent Doğanay (ORCID: https://orcid.org/0000-0002-2263-6689)
- Ingrid E. Lundberg (ORCID: https://orcid.org/0000-0002-6068-9212)
- Lynn M. Butler (ORCID: https://orcid.org/0000-0002-2352-8217)
- Antonella Notarnicola (ORCID: https://orcid.org/0000-0003-0272-2931)
- Tobias Sjöblom (ORCID: https://orcid.org/0000-0001-6668-4140)
- Per Venge (ORCID: https://orcid.org/0000-0001-5863-790X)
- Murat Dayangaç (ORCID: https://orcid.org/0000-0002-1240-7233)
- Tomas Olsson (ORCID: https://orcid.org/0000-0002-2938-1877)
- Göran M.L. Bergström (ORCID: https://orcid.org/0000-0003-4289-5722)
- Karin Stålberg (ORCID: https://orcid.org/0000-0001-5527-8796)
- Lingqi Meng (ORCID: https://orcid.org/0000-0001-9986-9205)
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Anders Gummesson (ORCID: https://orcid.org/0000-0003-0024-960X)
- Sara Cajander (ORCID: https://orcid.org/0000-0003-3921-4244)
- Linn Fagerberg (ORCID: https://orcid.org/0000-0003-0198-7137)
- Christian Unge
- Josefin Kenrick (ORCID: https://orcid.org/0000-0002-0110-5192)
- Christopher Sundling (ORCID: https://orcid.org/0000-0002-6138-690X)
- Wen Zhong (ORCID: https://orcid.org/0000-0002-7422-6104)
- Karin Gunnarsson (ORCID: https://orcid.org/0000-0001-9986-8341)
- Umit Haluk Yeşilkaya
- Ulf Gyllensten (ORCID: https://orcid.org/0000-0002-6316-3355)
- Oscar E. Simonson (ORCID: https://orcid.org/0000-0002-3552-5558)
- Murat Akyıldız (ORCID: https://orcid.org/0000-0002-2080-7528)
- Jakob Woessmann (ORCID: https://orcid.org/0000-0002-2283-7237)
- Sophia Björkander (ORCID: https://orcid.org/0000-0002-4600-2883)
- Cecilia Lindskog (ORCID: https://orcid.org/0000-0001-5611-1015)
- Anna Bergström (ORCID: https://orcid.org/0000-0002-7981-6314)
- Jochen M. Schwenk (ORCID: https://orcid.org/0000-0001-8141-8449)
- Adil Mardinoğlu (ORCID: https://orcid.org/0000-0002-4254-6090)
- Anders Sönnerborg (ORCID: https://orcid.org/0000-0001-8928-3374)
- Hasan Türkez (ORCID: https://orcid.org/0000-0002-7046-8990)
- Fredric Johansson (ORCID: https://orcid.org/0000-0001-5160-9543)
- Maximilian Julius Lautenbach (ORCID: https://orcid.org/0000-0001-5763-6964)
- Iva Gunnarsson (ORCID: https://orcid.org/0000-0002-4514-7706)
- Tadepally Lakshmikanth (ORCID: https://orcid.org/0000-0001-7256-5770)
- Karlis Pauksens
- Elisa Pin (ORCID: https://orcid.org/0000-0002-2158-2674)
- Per Oksvold (ORCID: https://orcid.org/0000-0003-3014-5502)
- Kalle von Feilitzen (ORCID: https://orcid.org/0000-0002-0257-7554)
- Thanadol Sutantiwanichkul (ORCID: https://orcid.org/0000-0002-1072-6863)
- Hanna Danielsson (ORCID: https://orcid.org/0000-0001-6959-7704)
- Miklós Lipcsey (ORCID: https://orcid.org/0000-0002-1976-4129)
- Lovisa Skoglund
- Erik Melén (ORCID: https://orcid.org/0000-0002-8248-0663)
- Anna Färnert (ORCID: https://orcid.org/0000-0001-7583-282X)
- Anne‐Sophie Merritt (ORCID: https://orcid.org/0000-0002-4497-1779)
- Sara Falck‐Jones (ORCID: https://orcid.org/0000-0003-1954-3200)
- Hong Yang (ORCID: https://orcid.org/0009-0002-0414-2471)
- Rebecka Hultgren (ORCID: https://orcid.org/0000-0002-8869-0493)
- Martin Zwahlen (ORCID: https://orcid.org/0000-0002-0064-4776)
- Elisabet Svenungsson (ORCID: https://orcid.org/0000-0003-3396-3244)
- Marie Wahren‐Herlenius (ORCID: https://orcid.org/0000-0002-0915-7245)
- Natallia Rameika
- Gizem Dinler Doğanay (ORCID: https://orcid.org/0000-0002-3586-1287)
- Marika Kvarnström (ORCID: https://orcid.org/0000-0002-4948-8380)
- David Kotol (ORCID: https://orcid.org/0000-0002-5388-3826)
- Anette Johnsson (ORCID: https://orcid.org/0000-0003-2944-1099)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Klara Sondén (ORCID: https://orcid.org/0000-0003-1585-8475)
- Anton Reepalu (ORCID: https://orcid.org/0000-0003-1690-8921)
- Yasin Hasan Balcıoğlu (ORCID: https://orcid.org/0000-0002-1336-1724)
- Mathias Uhlén (ORCID: https://orcid.org/0000-0002-4858-8056)
- Inger Kull (ORCID: https://orcid.org/0000-0001-6096-3771)
- Andreas Hober (ORCID: https://orcid.org/0000-0001-8947-2562)
- Henrik Lindman (ORCID: https://orcid.org/0000-0002-5871-268X)
- Gunilla Enblad (ORCID: https://orcid.org/0000-0002-0594-724X)
- Malin Enblad (ORCID: https://orcid.org/0000-0001-5900-0900)
- Khue Hua Tran-Minh (ORCID: https://orcid.org/0000-0002-8964-7489)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-3721-8586)
- Jonas Sundén‐Cullberg (ORCID: https://orcid.org/0000-0002-8189-4960)
- Κωνσταντίνος Αντωνόπουλος (ORCID: https://orcid.org/0000-0003-2781-3872)
- Ulrika Liljedahl (ORCID: https://orcid.org/0000-0002-1250-392X)
- Anna Smed‐Sörensen (ORCID: https://orcid.org/0000-0001-6966-7039)
- Meng Yuan (ORCID: https://orcid.org/0000-0002-9248-3294)
- Lars Klareskog (ORCID: https://orcid.org/0000-0001-9601-6186)
- Meltem Sen (ORCID: https://orcid.org/0000-0002-6248-7091)
- Mikael Åberg (ORCID: https://orcid.org/0000-0002-7858-8233)
- Petter Brodin (ORCID: https://orcid.org/0000-0002-8103-0046)
- Antti Siika (ORCID: https://orcid.org/0000-0002-2551-2526)
- María Jesús Iglesias (ORCID: https://orcid.org/0000-0003-4122-1945)
- Göran Hesselager
- Marie Holmqvist (ORCID: https://orcid.org/0000-0001-8996-5260)
- Fernanda Costa Svedman
- Anna Norrby‐Teglund (ORCID: https://orcid.org/0000-0001-9372-1795)
- Jacob Odeberg (ORCID: https://orcid.org/0000-0003-0996-1644)
- Fredrik Piehl (ORCID: https://orcid.org/0000-0001-8329-5219)
- Peter Nilsson (ORCID: https://orcid.org/0000-0002-4657-8532)
- Åsa Sivertsson (ORCID: https://orcid.org/0000-0001-8800-8469)
- María Bueno Álvez (ORCID: https://orcid.org/0000-0002-2669-7796)
- Jessica Nordlund (ORCID: https://orcid.org/0000-0001-8699-9959)
- Sofia Bergström (ORCID: https://orcid.org/0000-0003-2910-4754)
- Evelina Sjöstedt (ORCID: https://orcid.org/0000-0002-0327-7377)
- Piotr Nowak (ORCID: https://orcid.org/0000-0003-2747-0734)
- Laura González‐Aguilera (ORCID: https://orcid.org/0000-0003-3268-0509)
- Müjdat Zeybel (ORCID: https://orcid.org/0000-0001-5440-4623)
- Mattias Svensson (ORCID: https://orcid.org/0000-0003-1695-7934)
- Mattias Forsberg
- Emil Johansson
- Helén Nilsson Sköld
- Ozlem Altay
- M. Nguyen
- Emmanouil Apostolakis
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Bahçeşehir University (TR)
- Beth Israel Deaconess Medical Center (US)
- Karolinska University Hospital (SE)
- Koç University (TR)
- Harvard University (US)
- King's College London (GB)
- Lund University (SE)
- Örebro University (SE)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- Hammersmith Hospital (GB)
- Danderyds sjukhus (SE)
- Karolinska Institutet (SE)
- Istanbul Medipol University (TR)
- Bakırköy Psychiatric Hospital (TR)
- Thermo Fisher Scientific (Sweden) (SE)
- Stockholm South General Hospital (SE)
- Region Västra Götaland (SE)
- Sachs' Children and Youth Hospital (SE)
- Skåne University Hospital (SE)
- Acıbadem Kadıköy Hospital (TR)
- MRC London Institute of Medical Sciences (GB)
- University of Bergen (NO)
- Istanbul Technical University (TR)
- Atatürk University (TR)
- UiT The Arctic University of Norway (NO)
- KTH Royal Institute of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Science
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1126/science.adx2678
- Citations
- 18
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 13.61
Funders
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Science for Life Laboratory