Radiation-Triggered Payload Release Enhances Bispecific Antibody Efficacy
Radiation amplified antibody-drug conjugates use EGFR- and MET-targeted amivantamab to deliver cytotoxic payloads to tumors and minimize off-target toxicity by chemically uncaging payload activity with ionizing radiation.
Authors
- Jeremy M. Quintana (ORCID: https://orcid.org/0000-0001-9820-1297)
- Victoria E. Rodriguez-Castellanos (ORCID: https://orcid.org/0000-0003-2298-1818)
- Thomas S.C. Ng (ORCID: https://orcid.org/0000-0002-3676-1800)
- Leou Ismael Banla (ORCID: https://orcid.org/0000-0002-9290-5856)
- Miles A. Miller (ORCID: https://orcid.org/0000-0001-7638-8898)
- Ralph Weissleder (ORCID: https://orcid.org/0000-0003-0828-4143)
- Jose Manuel. Martin (ORCID: https://orcid.org/0009-0003-0061-087X)
- Marie A. Goemans (ORCID: https://orcid.org/0009-0008-9025-1888)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Center for Systems Biology (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0517
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36