LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
LSD1 inhibition enhances antigen presentation and reprograms the tumor microenvironment by inducing infiltration of T cells and dendritic cells, activating antitumor immunity and providing an epigenetic therapy for head and neck cancer.
Authors
- Bikash Sahay (ORCID: https://orcid.org/0000-0003-0905-733X)
- Lina Kroehling (ORCID: https://orcid.org/0000-0003-4996-7450)
- Amit Kumar Chakraborty (ORCID: https://orcid.org/0000-0001-7455-6579)
- J. Silvio Gutkind (ORCID: https://orcid.org/0000-0002-5150-4482)
- Maria A. Kukuruzinska
- Rajnikant Raut (ORCID: https://orcid.org/0000-0001-6963-5889)
- Manish V. Bais (ORCID: https://orcid.org/0000-0003-4198-7377)
- Stefano Monti (ORCID: https://orcid.org/0000-0002-9376-0660)
- Xaralabos Varelas (ORCID: https://orcid.org/0000-0002-2882-4541)
- Chumki Choudhury
Institutions
- Boston University (US)
- University of Florida (US)
- University of Massachusetts Boston (US)
- University of California San Diego (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3239
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61