FNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer
FNDC4 is a key driver of pancreatic cancer invasiveness and immunosuppression that can be targeted to reprogram the pancreatic tumor microenvironment and suppress tumor metastasis, offering a promising therapeutic strategy.
Authors
- Alexandra Aicher (ORCID: https://orcid.org/0000-0002-8920-9577)
- Li JingWei (ORCID: https://orcid.org/0000-0003-4595-584X)
- Baiyong Shen (ORCID: https://orcid.org/0000-0002-3994-248X)
- Berina Šabanović (ORCID: https://orcid.org/0000-0002-0883-3248)
- Da Fu (ORCID: https://orcid.org/0009-0006-0368-9757)
- Miriam Roberto (ORCID: https://orcid.org/0000-0002-3804-5031)
- Yilin Wang (ORCID: https://orcid.org/0000-0002-1255-767X)
- Serena Tondi (ORCID: https://orcid.org/0009-0003-6677-9766)
- Christopher Heeschen (ORCID: https://orcid.org/0000-0002-1158-8554)
- Ke Jiang (ORCID: https://orcid.org/0000-0001-7959-7716)
- Chenlei Wen (ORCID: https://orcid.org/0000-0003-3458-5409)
- Renfei Wu (ORCID: https://orcid.org/0000-0002-8847-7254)
- Chu-Hu Lai (ORCID: https://orcid.org/0000-0003-0643-2376)
- Yu Jiang (ORCID: https://orcid.org/0000-0001-5214-3183)
- Xiaohan Jin
- Yuntao Yang (ORCID: https://orcid.org/0009-0009-2703-5872)
- Shenghui Huang (ORCID: https://orcid.org/0000-0002-3714-1961)
- Shuang Lin Dong
Institutions
- Shanghai Jiao Tong University (CN)
- China Medical University (TW)
- Ruijin Hospital (CN)
- Shanghai Cancer Institute (CN)
- Candiolo Cancer Institute (IT)
- Department of Public Health (US)
- University of Turin (IT)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1001
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39