Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study
We found numerous metabolites and pathways that were associated with rest-activity rhythm variables in older women, suggesting a potentially wide-reaching role of diurnal behaviors in human metabolism and health. Statement of Significance In this metabolomics study in older women, we found a large number of metabolites that were associated with rest-activity rhythms. These metabolites represented a wide range of biochemical classes and metabolic pathways. This analysis also confirmed numerous metabolite associations we have recently found in a sample of older men in the Osteoporotic Fractures in Men study, lending further support to a wide-reaching role of circadian rhythms and diurnal behaviors in human health. To the best of our knowledge, our two studies were the first metabolomics investigations focusing on rest-activity rhythm characteristics. With further validation studies, we anticipate that findings from these studies will contribute to the broader endeavor to understand, diagnose, and treat circadian rhythm-related disorders, with potential benefits for human health.
Authors
- Chris Ho Ching Yeung (ORCID: https://orcid.org/0000-0003-2753-1728)
- Aladdin H. Shadyab (ORCID: https://orcid.org/0000-0002-9693-0522)
- Kathleen M. Hayden (ORCID: https://orcid.org/0000-0002-7745-3513)
- Katie L. Stone (ORCID: https://orcid.org/0000-0003-2797-3171)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- Lingxiao Zhang (ORCID: https://orcid.org/0000-0002-7066-6065)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- Qian Xiao (ORCID: https://orcid.org/0000-0002-8388-1178)
- Andrea Z. LaCroix (ORCID: https://orcid.org/0000-0002-9532-976X)
- Kyoung A Lee (ORCID: https://orcid.org/0000-0002-9451-9377)
- Yuan Huang
- Jiu-Chiuan Chen
- JoAnn E. Manson (ORCID: https://orcid.org/0000-0002-9426-7595)
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- University of California, San Francisco (US)
- California Pacific Medical Center (US)
- Yale University (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- The University of Texas Health Science Center (US)
- Wake Forest University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- SLEEP
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/sleep/zsaf320
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81