Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis
Continuous oral ingestion of SiO<sub>2</sub> NPs induced liver-specific accumulation, and caused abnormal deposition of liver lipids, senescence and fibrosis via microbiota-gut-liver crosstalk. Microbial therapy involving probiotic supplementation mitigated SiO<sub>2</sub> NPs-induced hepatotoxicity and exerted protective effects. This study provides a scientific reference for the rational application, risk management, and prevention of the harmful effects caused by SiO<sub>2</sub> NPs.
Authors
- Longxing Wang
- Jun Xiao (ORCID: https://orcid.org/0000-0003-4004-3382)
- Lisha Du (ORCID: https://orcid.org/0009-0006-7374-1565)
- Huan Wang (ORCID: https://orcid.org/0000-0001-7042-3306)
- Jiajun Yin
- Xiaofei Han (ORCID: https://orcid.org/0000-0001-5021-6262)
- Mengyuan Lv
- Ju Wu
- Yanjie Dou
Institutions
- Dalian Institute of Chemical Physics (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12951-025-03711-5
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64