A pyrophosphatase that regulates lipid precursors of <i>N</i>-glycosylation
The oligosaccharide used for protein N-glycosylation in the ER is built as a glycolipid. A recent study by Li, Suzuki, and colleagues (https://doi.org/10.1083/jcb.202501239) identifies a long-sought enzyme that hydrolyzes this lipid as part of a possible homeostatic/quality control mechanism.
Authors
- Anant K. Menon (ORCID: https://orcid.org/0000-0001-6924-2698)
Institutions
- Cornell University (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1083/jcb.202509041
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health