IP8-FLUORESCE: A Prospective Paired Cohort Study Evaluating the Diagnostic Accuracy of Fluorescence Confocal Microscopy for Real-time Assessment of Surgical Margins in Radical Prostatectomy
FCM is a feasible, rapid technique for intraoperative margin assessment in RP. Its diagnostic accuracy is reasonable for clinically significant, longer PSMs, but limited for shorter margins, particularly at the apex. These findings support further evaluation in a clinical utility study to determine whether intraoperative FCM can guide surgical decision-making, optimise nerve sparing, and ultimately improve oncological and functional outcomes.
Authors
- Ben J Challacombe (ORCID: https://orcid.org/0000-0001-8631-0314)
- Hashim U. Ahmed (ORCID: https://orcid.org/0000-0003-1674-6723)
- Archana Gopalakrishnan (ORCID: https://orcid.org/0000-0001-6145-5146)
- Larissa Mendes
- Emma Cullen
- Giles Hellawell
- Taimur T. Shah (ORCID: https://orcid.org/0000-0003-1642-1208)
- Francesca Fiorentino (ORCID: https://orcid.org/0000-0001-9817-6634)
- R. Almeida-Magana (ORCID: https://orcid.org/0000-0002-3437-1649)
- Mathias Winkler (ORCID: https://orcid.org/0000-0002-2553-5816)
- Greg L. Shaw (ORCID: https://orcid.org/0000-0003-3480-2100)
- Martin J. Connor (ORCID: https://orcid.org/0000-0003-4033-7508)
- Alexander Light (ORCID: https://orcid.org/0000-0001-7246-3651)
- Nikhil Mayor (ORCID: https://orcid.org/0000-0003-2681-2501)
- Aiman Haider (ORCID: https://orcid.org/0000-0002-7005-4245)
- Ranil Johann Boaz (ORCID: https://orcid.org/0000-0002-0770-3839)
- Anna Silvanto
- Chiu‐Wan Ng (ORCID: https://orcid.org/0000-0002-7687-2310)
- Bijan Khoubehi (ORCID: https://orcid.org/0000-0002-8377-9595)
- P. Cathcart (ORCID: https://orcid.org/0000-0001-7528-6099)
- Eoin Dinneen (ORCID: https://orcid.org/0000-0002-4309-3257)
Institutions
- National Health Service (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Imperial College Healthcare NHS Trust (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Prostate Cancer Research (GB)
- Respiratory Clinical Trials (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Urology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.eururo.2025.09.4171
- Citations
- 6
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.11