ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage
LOXL2 expression is down-regulated in degenerated discs, and its overexpression inhibits the Notch pathway and delays NPCs senescence. The LNP-LOXL2@Gel hydrogel system, which can effectively alleviate IDD by synergistically integrating the antiaging effect of LOXL2 and the ROS scavenging ability of PVA-tsPBA, provides a new targeting therapeutic strategy for the clinical treatment of IDD.
Authors
- Xinxin Miao
- Xiaokun Zhao (ORCID: https://orcid.org/0000-0002-3425-1882)
- Guanfeng Huang
- Xigao Cheng (ORCID: https://orcid.org/0000-0002-6105-1499)
- Chongzhi Pan (ORCID: https://orcid.org/0000-0003-1600-7779)
- Rui Ding (ORCID: https://orcid.org/0000-0001-9730-0744)
- Xiao‐Long Chen (ORCID: https://orcid.org/0000-0003-3796-9248)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7217-0111)
- Yang Li (ORCID: https://orcid.org/0000-0001-8186-2435)
- Jiajun Xie (ORCID: https://orcid.org/0009-0001-3369-7225)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12951-025-03718-y
- Citations
- 4
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.89