Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy
Collectively, our findings establish the miR-145-3p/IREB2/ferroptosis axis as an important regulator of BRONJ pathology and demonstrate that exosomal delivery of miR-145-3p not only ameliorates localized BRONJ but also substantially reinstates the systemic osteogenic potential of jawbone-derived MSCs, offering a pre-clinical promising strategy to combat both BRONJ and associated bone loss disorders.
Authors
- Bingyao Liu (ORCID: https://orcid.org/0000-0002-7369-7019)
- Wei Wei (ORCID: https://orcid.org/0000-0002-2234-4459)
- Bo Chen (ORCID: https://orcid.org/0000-0003-3383-3992)
- Lei Zhu (ORCID: https://orcid.org/0000-0001-5869-4410)
- Lei Jin (ORCID: https://orcid.org/0000-0001-5630-2081)
- Han Su (ORCID: https://orcid.org/0000-0001-7716-3033)
- Yi Shuai (ORCID: https://orcid.org/0000-0003-4950-2055)
- Tao Jiang (ORCID: https://orcid.org/0009-0007-6524-5382)
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Drum Tower Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12951-025-03745-9
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Nanjing University