OptoBrain: A Wireless Sensory Interface for Optogenetics

Optogenetics leverages light to control neural circuits, but traditional systems are often bulky and tethered, limiting their use. This work introduces OptoBrain, a novel, portable wireless system for optogenetics designed to overcome these challenges. The system integrates modules for multichannel data acquisition, smart neurostimulation, and continuous processing, with a focus on low-power and low-voltage operation. OptoBrain features up to eight neuronal acquisition channels with a low input-referred noise (e.g., 0.99 µVRMS at 250 sps with 1 V/V gain), and reliably streams data via a Bluetooth 5.0 link at a measured throughput of up to 400 kbps. Experimental results demonstrate robust performance, highlighting its potential as a simple, practical, and low-cost solution for emerging optogenetics research centers and enabling new avenues in neuroscience.