Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan
The glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is implicated in the pathology of muscular dystrophies. Novel tools are needed to study its rare and intriguing <i>O</i>-mannosyl glycans. This report describes the synthesis and evaluation of alkyne-tagged ribitol-5-phosphate derivatives for the metabolic labelling of α-dystroglycan in mammalian cells.
Authors
- Saeed Akkad (ORCID: https://orcid.org/0000-0002-7271-0496)
- Lloyd D. Murphy (ORCID: https://orcid.org/0000-0002-6129-292X)
- Eva Wan
- Kathryn E. Huxley (ORCID: https://orcid.org/0000-0001-5136-8401)
- Mia Shandell (ORCID: https://orcid.org/0000-0002-7864-758X)
- Angelo Lopez (ORCID: https://orcid.org/0000-0002-9397-7376)
- Lianne I. Willems (ORCID: https://orcid.org/0000-0001-5411-1329)
- Luke Julyan
- Morgan E Batiste-Simms
- Greg Laughlan McNeil (ORCID: https://orcid.org/0009-0004-3927-9034)
Institutions
- University of York (GB)
Publication Details
- Journal
- RSC Chemical Biology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cb00187k
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ohio State University
- Yorkshire Forward
- European Commission
- Engineering and Physical Sciences Research Council