m <sup>6</sup> A Eraser FTO Promotes ATF3 Expression Impairing Podocyte Autophagy in Diabetic Nephropathy
FTO impairs podocyte autophagy in DKD via m6A demethylation-mediated stabilization of ATF3. Targeting the FTO-ATF3 axis may offer a promising therapeutic strategy to preserve podocyte integrity and mitigate DKD progression.
Authors
- Aisha Zhang (ORCID: https://orcid.org/0000-0002-9741-1169)
- Jiahui Chen (ORCID: https://orcid.org/0000-0002-0742-8697)
- Tingfei Xie (ORCID: https://orcid.org/0000-0002-7857-4392)
- Xiaolu Sui (ORCID: https://orcid.org/0000-0001-8585-6104)
- Xiaoling Zhong
- Jianyu Chen (ORCID: https://orcid.org/0000-0003-2348-9948)
- Jihong Chen (ORCID: https://orcid.org/0000-0002-1676-5732)
- Yunpeng Xu (ORCID: https://orcid.org/0009-0001-1820-5798)
- Yanzi Zhang (ORCID: https://orcid.org/0000-0002-4621-9978)
- Jisu Xue
- Wei Liu (ORCID: https://orcid.org/0009-0007-9327-2732)
Institutions
- Guangdong Medical College (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1159/000547688
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00