Causal effect of serum lipopolysaccharide activity levels and inflammatory proteins on Alzheimer's disease: A Mendelian randomization study combined with meta-analysis in a large-scale cohort
This study suggested that serum LPS activity level may present a risk effect in early onset sporadic AD. Two inflammatory proteins AXIN1 and IL-1 alpha were associated with the risk of sporadic AD. These findings provide a new perspective for the early diagnosis and treatment of sporadic and familial AD.
Authors
- Fengfeng Jia (ORCID: https://orcid.org/0000-0002-1506-2007)
- Jianjun Zhu (ORCID: https://orcid.org/0000-0001-5338-7825)
- Li Niu (ORCID: https://orcid.org/0000-0003-0837-9345)
- Liping Zhao (ORCID: https://orcid.org/0000-0001-9694-7140)
- Ming Liu (ORCID: https://orcid.org/0000-0001-9785-6056)
- Jin Zhang (ORCID: https://orcid.org/0000-0003-0009-824X)
- Guoqing Zhao
- Yubo Li
- Fan Lü (ORCID: https://orcid.org/0009-0002-5022-7767)
- Hao Wu (ORCID: https://orcid.org/0000-0002-9310-8998)
Institutions
- Shanxi Medical University (CN)
- Xian Central Hospital (CN)
- Shanxi Coal Transportation and Sales Group (China) (CN)
- Taiyuan Heavy Industry (China) (CN)
- Taiyuan Institute of Technology (CN)
- Taiyuan Central Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- China Coal Research Institute (China) (CN)
- Taiyuan University of Science and Technology (CN)
- Taiyuan University of Technology (CN)
Publication Details
- Journal
- Journal of Alzheimer s Disease Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/25424823251385589
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00