The association between bilirubin and vestibular dysfunction in the United States in middle-aged and older people insights from NHANES 1999-2004 and Mendelian randomization analysis
Moderate STB concentrations may reduce vestibular dysfunction risk. This protective effect is causally mediated by bilirubin in individuals under 60, suggesting bilirubin homeostasis could be a novel target for prevention. The reversed association in older adults warrants further investigation.
Authors
- Jing Luo (ORCID: https://orcid.org/0000-0001-6483-4264)
- Hengkang He
- Fang Zhang (ORCID: https://orcid.org/0000-0002-3707-9272)
- Jingwen Zhang (ORCID: https://orcid.org/0000-0002-2696-2406)
- Xiong Zhang (ORCID: https://orcid.org/0000-0003-2235-569X)
- Jianhui Zhang (ORCID: https://orcid.org/0009-0005-0102-1051)
- Yixi Xiao (ORCID: https://orcid.org/0009-0001-9495-8089)
- Yang Tian
Institutions
- Third People's Hospital of Chengdu (CN)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1093/gerona/glaf224
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00