Association of serum complement C3 level with disease severity in primary pterygium

Lower serum C3 levels were associated with advanced stromal opacification in pterygium, indicating possible complement activation in severe disease. While ANA was frequently positive, it did not correlate with clinical severity. These findings suggest that complement C3 may serve as a potential biomarker for advanced pterygium.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-09-23
DOI
https://doi.org/10.3389/fmed.2025.1671768
Primary Topic
Corneal Surgery and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Association of serum complement C3 level with disease severity in primary pterygium

Kyoung Woo Kim, Seung Hyeun Lee, Jung Sun Heo, Young In Yun
Frontiers in Medicine
Corneal Surgery and Treatments
article

Association of serum complement C3 level with disease severity in primary pterygium

Kyoung Woo Kim, Seung Hyeun Lee, Jung Sun Heo, Young In Yun
article en

Abstract

Lower serum C3 levels were associated with advanced stromal opacification in pterygium, indicating possible complement activation in severe disease. While ANA was frequently positive, it did not correlate with clinical severity. These findings suggest that complement C3 may serve as a potential biomarker for advanced pterygium.

Frontiers in MedicineVol. 12
Dongguk University Ilsan Hospital (KR), Chung-Ang University Hospital (KR)
National Research Foundation, National Research Foundation of Korea, Ministry of Education, Science and Technology
Openalex Percentile: Top 58%
Corneal Surgery and Treatments
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