Biomimetic synthesis of a benzobisthiazole-based conjugated polymer for pH-responsive drug delivery and synergistic tumor therapy
A benzodithiophene-based conjugated polymer (termed as DPDMP) with high water-dispersibility, biocompatibility, and superior photothermal conversion efficiency was synthesized using a biomimetic click reaction. DPDMP can establish pH-responsive boronate ester bonds with bortezomib, enabling an integrated approach to tumor photothermal and chemotherapy.
Authors
- Yen Wei (ORCID: https://orcid.org/0000-0001-5950-0163)
- Yu Wu (ORCID: https://orcid.org/0000-0002-5570-270X)
- Peng Luo (ORCID: https://orcid.org/0000-0002-8215-2045)
- Kun Zhang (ORCID: https://orcid.org/0000-0001-8100-5281)
- Shaorong Huang (ORCID: https://orcid.org/0009-0009-0801-3555)
- Xiaoyong Zhang (ORCID: https://orcid.org/0000-0001-8843-875X)
- Yi Ouyang (ORCID: https://orcid.org/0000-0001-5151-5272)
- Qi Lai (ORCID: https://orcid.org/0000-0002-1524-4556)
- Meiying Liu (ORCID: https://orcid.org/0009-0000-9797-3690)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04705f
- Primary Topic
- Dendrimers and Hyperbranched Polymers
- Type
- article
- Field-Weighted Citation Impact
- 0.00