A multicenter study on the prognostic value of prednisone response in pediatric acute lymphoblastic leukemia
In this large real-world Chinese cohort, PR was not an independent prognostic marker but was strongly associated with early MRD burden. These findings support the contextual use of PR as a practical surrogate for MRD in resource-limited settings, and highlight the need to reconsider its role in modern risk-adapted treatment strategies.
Authors
- Zou Ya-wei
- Yan‐Lai Tang (ORCID: https://orcid.org/0000-0002-2649-5270)
- Wuqing Wan
- Li-Li Liu
- Yunyan He (ORCID: https://orcid.org/0000-0001-7181-4878)
- Ming Cheng (ORCID: https://orcid.org/0000-0001-5419-7775)
- Zijun Zhen (ORCID: https://orcid.org/0000-0002-4442-0897)
- Qi-wen Chen
- Wenguang Jia
- Liuhua Liao
- Xian-Ling Kong
- Qiao-Ru Li
- Huirong Mai (ORCID: https://orcid.org/0000-0002-8970-9221)
- Shilin Liu (ORCID: https://orcid.org/0000-0002-3704-3798)
- Yang Li (ORCID: https://orcid.org/0000-0001-9612-2704)
- Yajie Zhang (ORCID: https://orcid.org/0000-0002-3439-2773)
- Ning Liao (ORCID: https://orcid.org/0000-0002-0836-9043)
- Yating Zhang (ORCID: https://orcid.org/0000-0002-6927-8452)
- Jia-Tong Dai
- Jie Cai (ORCID: https://orcid.org/0000-0002-2691-0411)
- Ying Liu (ORCID: https://orcid.org/0000-0001-5532-8554)
- Xing‐Jiang Long
- Lina Wang (ORCID: https://orcid.org/0000-0003-3665-5706)
- Yesheng Ling
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Guangdong Medical College (CN)
- Shantou University (CN)
- Liuzhou General Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhongshan People's Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Guangzhou First People's Hospital (CN)
- Zhujiang Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Huizhou Central People's Hospital (CN)
- Boai Hospital of Zhongshan (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Children's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Annals of Hematology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1007/s00277-025-06656-9
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00