T cell receptor associated transmembrane adaptor 1 (TRAT1) modulates human Th17 and Treg responses via PI3-kinase and STAT dependent mechanisms
TRAT1 acts as a dual regulator of human CD4⁺ T cell function, limiting effector activation through modulation of intracellular signaling and supporting regulatory T cell-mediated suppression. These findings reveal a novel mechanism of immune regulation with potential implications for the development of cell-based immunotherapies.
Authors
- Tobias Frey (ORCID: https://orcid.org/0000-0002-6274-9864)
- Marlene Hollenstein (ORCID: https://orcid.org/0009-0003-5417-5594)
- Georg Stary (ORCID: https://orcid.org/0000-0003-1746-4250)
- Annika Lampl
- Anna Kaempf
- Johanna Strobl (ORCID: https://orcid.org/0000-0003-3606-2185)
- Klaus G. Schmetterer (ORCID: https://orcid.org/0000-0001-9328-4871)
- Ralf Schmidt (ORCID: https://orcid.org/0000-0002-6697-0363)
- Julia Eckl‐Dorna (ORCID: https://orcid.org/0000-0001-5981-1607)
- K. Schaffer (ORCID: https://orcid.org/0000-0001-5046-9251)
- J Kovarík (ORCID: https://orcid.org/0000-0002-0206-082X)
- Christina Kandolf-Zumpf
Institutions
- Austrian Academy of Sciences (AT)
- CeMM Research Center for Molecular Medicine (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12964-025-02429-z
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund