Analysis of a Modified Version of the Inventory of Non‐Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the <scp>EFACTS</scp> Study
The modified INAS sum showed good responsiveness over 5 years but not over 1-3 years. It may supplement existing outcome measures, contributing to holistic assessment of this multisystem disease, especially in non-ambulatory patients, in whom ataxia-focused measures may show ceiling effects, and children, who typically progress faster. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Myriam Rai
- Stella A. Glasmacher (ORCID: https://orcid.org/0000-0003-1165-9153)
- Imis Dogan (ORCID: https://orcid.org/0000-0002-6632-197X)
- Wolfgang Nachbauer (ORCID: https://orcid.org/0000-0001-8292-3690)
- Claire Ewenczyk (ORCID: https://orcid.org/0000-0002-4864-6287)
- Thomas Klopstock (ORCID: https://orcid.org/0000-0003-2805-4652)
- R.-D Hilgers (ORCID: https://orcid.org/0000-0002-5945-1119)
- Alexandra Dürr (ORCID: https://orcid.org/0000-0002-8921-7104)
- Jörg B. Schulz (ORCID: https://orcid.org/0000-0002-8903-0593)
- Thomas Klockgether (ORCID: https://orcid.org/0000-0001-6174-5442)
- Caterina Mariotti (ORCID: https://orcid.org/0000-0003-2405-3564)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Zofia Fleszar
- Michael Parkinson (ORCID: https://orcid.org/0000-0002-8278-0877)
- Paola Giunti (ORCID: https://orcid.org/0000-0003-3508-4788)
- Sylvia Boesch (ORCID: https://orcid.org/0000-0003-1657-7368)
- Marcus Grobe‐Einsler (ORCID: https://orcid.org/0000-0002-1808-2134)
- Heike Jacobi
- Claudia Stendel (ORCID: https://orcid.org/0000-0002-4234-8393)
- Ludger J. Schöls (ORCID: https://orcid.org/0000-0001-7774-5025)
- Massimo Pandolfo (ORCID: https://orcid.org/0000-0001-5230-5787)
- Francisco Javier Rodríguez de Rivera Garrido (ORCID: https://orcid.org/0000-0001-9008-7629)
- Ilaria Giordano
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Innsbruck Medical University (AT)
- Inserm (FR)
- Forschungszentrum Jülich (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- Hospital Universitario La Paz (ES)
- German Center for Neurodegenerative Diseases (DE)
- Sorbonne Université (FR)
- Hospital La Paz Institute for Health Research (ES)
- Munich Cluster for Systems Neurology (DE)
- Friedrich Baur Stiftung (DE)
- Friedreich's Ataxia Research Alliance (US)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University College London (GB)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1002/mds.70084
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Biogen
- Eisai
- Ipsen