Polymerase theta inhibition impairs tumor growth and amplifies melphalan-induced DNA damage in multiple myeloma
Collectively, our results confirm Polθ as a promising prognostic biomarker and highlight its potential to serve as a synthetic lethal target that can be used in combination with melphalan for the treatment of MM.
Authors
- Fei Zhao (ORCID: https://orcid.org/0000-0003-1393-3734)
- Wayne Xin Zhao (ORCID: https://orcid.org/0000-0002-8333-6196)
- Yu Hu (ORCID: https://orcid.org/0000-0002-2815-4568)
- Lifei Liu (ORCID: https://orcid.org/0000-0002-4670-9758)
- Bo Zhang (ORCID: https://orcid.org/0000-0003-1288-1549)
- Chi Ma (ORCID: https://orcid.org/0000-0002-4302-9079)
- Chunyan Sun
- Liping Zuo (ORCID: https://orcid.org/0000-0002-6268-8790)
- Aoshuang Xu
- Qun Li
Institutions
- Humanwell Healthcare Group (China) (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12967-025-07065-2
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00