Cigarette smoke extract promotes metastasis and oxaliplatin resistance in colon adenocarcinoma through GDF15/ERBB2/AKT pathway
CSE promoted COAD metastasis and L-OHP resistance by upregulating GDF15, which activated the ERBB2/AKT/SLC7A11 axis. Targeting GDF15 may offer therapeutic potential to overcome cigarette-aggravated COAD progression.
Authors
- Baichuan Zhou
- Xin Hu (ORCID: https://orcid.org/0000-0002-8160-8362)
- Weijie Wang (ORCID: https://orcid.org/0000-0003-1442-961X)
- Aman Xu (ORCID: https://orcid.org/0000-0002-6308-0488)
- Wen G. Jiang (ORCID: https://orcid.org/0000-0002-3283-1111)
- Ye Wang (ORCID: https://orcid.org/0000-0003-0764-2279)
Institutions
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s40001-025-03233-8
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University
- University of Science and Technology of China
- School of Life Sciences and Biotechnology Division of Life Sciences, Korea University