Sex-related differences in phenotype and nigro-striatal degeneration of c-rel-/- mouse model of Parkinson’s disease
Our results show that, differently from aged males, c-rel<sup>-/-</sup> females do not develop a parkinsonian behavior, in line with evidence from the human PD. The phenotype mice display a nigral dopaminergic neuron degeneration but conserved nigrostriatal fiber density. The degeneration and PD-like symptoms are compatible with the sex-related differences on incidence and symptoms progression observed in PD patients.
Authors
- Michele Mario Gennari
- Federico Del Gallo (ORCID: https://orcid.org/0000-0003-0248-2456)
- Chiara Fritzsch
- Edoardo Parrella (ORCID: https://orcid.org/0000-0003-0365-5144)
- Marina Bentivoglio (ORCID: https://orcid.org/0000-0003-4958-9795)
- Marina Benarese
- Marina Pizzi (ORCID: https://orcid.org/0000-0002-4857-5204)
- Vanessa Porrini (ORCID: https://orcid.org/0000-0001-8222-155X)
- Anna Andrioli (ORCID: https://orcid.org/0000-0001-8542-263X)
- Paolo Francesco Fabene (ORCID: https://orcid.org/0000-0002-9644-4399)
Institutions
- University of Verona (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s13293-025-00761-0
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Università degli Studi di Brescia