Size-dependent immunomodulation by MSC secretome: soluble factors target innate pathways, components larger than 100 kDa regulate T cell proliferation
These findings indicate a complex mechanism of action where soluble factors and components larger than 100 kDa modulate immunity but through different pathways. This mechanistic distinction highlights the importance of considering secretome composition when designing cell-free MSC-based therapies.
Authors
- Shony Lemieux
- Christophe Wong
- Nassima Bekaddour (ORCID: https://orcid.org/0000-0001-7777-5929)
- Jean‐Philippe Herbeuval (ORCID: https://orcid.org/0000-0001-8114-8012)
- Thibaut Fourniols
- Jeanne Volatron
- Isaure Rous
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Paris Cité (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- Association Francaise contre les Myopathies (FR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s13287-025-04670-2
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation Bettencourt Schueller