Neutrophil activation in juvenile dermatomyositis: associations with muscle function and disease progression
These findings highlight calprotectin and MPO-DNA as potential biomarkers for JDM muscle inflammation and functional outcomes. These results suggest that neutrophil activation plays a key role in JDM pathogenesis and may provide insights into disease monitoring and treatment strategies.
Authors
- Antonin Lévy (ORCID: https://orcid.org/0000-0003-4798-8899)
- Jorge A. González-Chapa (ORCID: https://orcid.org/0000-0001-5231-2469)
- Susan Shenoi (ORCID: https://orcid.org/0000-0002-2495-594X)
- Christian Lood (ORCID: https://orcid.org/0000-0002-6171-1952)
- Payton Hermanson
- Yang Wu (ORCID: https://orcid.org/0000-0002-0128-7280)
- Qian Wang
- Ting Wang (ORCID: https://orcid.org/0000-0002-8974-596X)
- Jia Shi (ORCID: https://orcid.org/0000-0002-7406-3560)
- Abhinav Janappareddi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of Washington (US)
- Peking Union Medical College Hospital (CN)
- Rady Children's Hospital-San Diego (US)
- Seattle Children's Hospital (US)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12969-025-01152-w
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seattle Children's Research Institute
- Children’s Hospital of Wisconsin Research Institute
- Cure JM Foundation
- China Scholarship Council