Therapeutic potential of hAMSCs in ligament regeneration: insights from the UCA1-miR-16-5p-FGF2 pathway
In this study, we identified the presence of a ceRNA network involving the UCA1-miR-16-5p-FGF2 axis in hAMSCs. By regulating the key components of this axis, we can modulate the differentiation of hAMSCs into ligament cells, providing a potential therapeutic strategy for promoting tendon-bone healing.
Authors
- Hao Yu (ORCID: https://orcid.org/0000-0001-6724-9917)
- Gang Zou (ORCID: https://orcid.org/0000-0003-2163-3897)
- Jiachen Peng (ORCID: https://orcid.org/0000-0001-7267-0650)
- Yiran Li (ORCID: https://orcid.org/0000-0001-7922-7766)
- Huaize Dong
- Jibin Yang
- Jin Yang (ORCID: https://orcid.org/0000-0003-1497-8133)
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s13287-025-04682-y
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00