Pregnancy of unknown location — still diagnostics and therapeutic problem

Pregnancy of unknown location is still a significant diagnostic and therapeutic problem in the population of women of reproductive age. The management of women with PUL can vary widely, as there are still no standardized guidelines for the diagnosis and treatment of such a clinical situation. The diagnostic effort in this initial diagnosis should be directed both to the exclusion of ectopic pregnancy, which carries a significant risk to the patient, as well as a properly implanted pregnancy, since the implementation of treatment may be associated with adverse effects on its subsequent fate. The authors reviewed the literature on this issue, taking into account their own experience in the management of pregnancies of unknown location. They conducted a critical analysis of the literature on PUL found in MEDLINE, Google Scholar, the Cochrane Central Register of Controlled Trials, and Clinical Trials.