Exploring the mechanism of action of astragaloside in the treatment of osteoarthritis based on network pharmacology
AST treatment of OA is characterized by multi-target and multi-pathway interactions, and its key target genes act on OA by affecting endothelial cell permeability, regulating synovial, chondrocyte survival, proliferation, and extracellular matrix synthesis, etc., and its molecular mechanism involves the Src/PI3K/Akt, NF-κB, MAPK, and TLRs signaling pathways.
Authors
- Xiangming Lin
- Guangdong Zhou (ORCID: https://orcid.org/0000-0003-2488-2733)
- Baihui Li (ORCID: https://orcid.org/0009-0004-7660-0480)
- Juncen Li (ORCID: https://orcid.org/0000-0001-7868-6100)
- Daiying Song
- Di Wang (ORCID: https://orcid.org/0000-0002-6221-0949)
- Yajie Wang (ORCID: https://orcid.org/0000-0002-3285-2537)
- Yu Liu (ORCID: https://orcid.org/0009-0006-5302-8009)
- Wei Xu (ORCID: https://orcid.org/0000-0002-9874-4184)
- Yanfeng Sun (ORCID: https://orcid.org/0009-0005-3208-0054)
Institutions
- Weifang Medical University (CN)
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Advanced Tissue (United States) (US)
- Swiss National Science Foundation (CH)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12938-025-01445-x
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China