Antimicrobial activity of <i>Andrographis paniculata</i> intimate wash and commercial formulations against vaginal pathogens using the broth microdilution method

The <i>A. paniculata</i> intimate wash showed the highest percentage of microbial inhibition across all tested pathogens. It also recorded MIC and MBC values of 3.125 mg/ml against <i>E. coli</i> and <i>C. albicans</i>. Among commercial products, SebaMed^® demonstrated the strongest antimicrobial effect against <i>S. agalactiae</i> at the same MIC concentration. The study concluded that the <i>A. paniculata</i> intimate wash is a potentially effective treatment for selected vaginal pathogens at higher concentrations and may promote the growth of <i>L. crispatus</i>. SebaMed^®, a clinically established product, also exhibited notable antimicrobial properties. However, further <i>in vivo</i> and clinical trials are necessary to confirm efficacy and assess toxicity. The study highlights the need for continued research into the potential of herbal intimate washes for treating vaginal infections.