Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice
In summary, our data suggest that CB<sub>2</sub> located at peripheral sites (skeletal muscle, immune cells, others) may be responsible of therapeutic effects showed by compounds targeting these receptors in amyotrophic lateral sclerosis. Our study may be of critical importance to move CB<sub>2</sub> agonists in amyotrophic lateral sclerosis towards the clinical scenario.
Authors
- Isabel Machín-Díaz (ORCID: https://orcid.org/0000-0001-6483-5726)
- Paweł Dżygiel (ORCID: https://orcid.org/0009-0006-4722-4070)
- Claudia Gonzalo‐Consuegra (ORCID: https://orcid.org/0000-0002-4062-7516)
- Carmen Rodríguez‐Cueto (ORCID: https://orcid.org/0000-0002-3891-4049)
- Matthias Wittwer (ORCID: https://orcid.org/0000-0003-1359-4795)
- Javier Fernández‐Ruíz (ORCID: https://orcid.org/0000-0002-4490-0604)
- Eva de Lago (ORCID: https://orcid.org/0000-0002-6260-3777)
- Uwe Grether (ORCID: https://orcid.org/0000-0002-3164-9270)
- Diego Clemente (ORCID: https://orcid.org/0000-0003-4829-9497)
- María Cabañas-Cotillas
- Marta Gómez‐Almería
- Alberto Jiménez-Amor
Institutions
- Roche (Switzerland) (CH)
- Universidad Complutense de Madrid (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Servicio de Salud de Castilla La Mancha (ES)
- Hospital Nacional de Parapléjicos (ES)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12964-025-02418-2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III