Integrating the secretome and interactome to identify novel biomarkers and therapeutic targets in colorectal cancer
This study highlights FGFR4, FLT1, and WNT5A as key diagnostic and therapeutic biomarkers for CRC, with their relevance varying based on the tumor's site of origin. Leveraging these findings, we propose Dovitinib and Nintedanib as promising targeted therapies for CRC. These insights can enhance current treatment strategies and pave the way for future in vivo and in vitro studies, driving progress in CRC research and therapy.
Authors
- Gabriel Henrique Caxali (ORCID: https://orcid.org/0000-0002-4251-3416)
- Lucas Tadeu Bidinotto (ORCID: https://orcid.org/0000-0002-6909-8347)
- Mirian Carolini Esgoti Aal (ORCID: https://orcid.org/0000-0002-8444-4092)
- Jakeline Santos Oliveira (ORCID: https://orcid.org/0000-0002-3256-8683)
- Robson Francisco Carvalho (ORCID: https://orcid.org/0000-0002-4901-7714)
- Flávia Karina Delella (ORCID: https://orcid.org/0000-0001-6362-5882)
- Catherine Wesselka Garcia Osvaldo
Institutions
- Centro Universitário da Fundação Educacional de Barretos (BR)
- Hospital de Câncer de Barretos (BR)
- Instituto Barretos de Tecnologia (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12964-025-02424-4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior