Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS
NAFLD patients without cirrhosis showed significantly a reduced ALPS index compare to matched controls, indicating potential alterations in GS function. These alterations correlated with cognitive performance and clinical indicators, implying a possible link between GS function and cognitive performance in NAFLD that requires longitudinal validation.
Authors
- Xiaoyan Huang (ORCID: https://orcid.org/0000-0002-7959-423X)
- Shaoqing Chen (ORCID: https://orcid.org/0000-0002-6700-292X)
- Kun Shu
- Jiawen Song
- Peng Wu (ORCID: https://orcid.org/0000-0002-2042-5730)
- Yongjin Zhou (ORCID: https://orcid.org/0000-0002-0067-8466)
- Xinjian Ye (ORCID: https://orcid.org/0000-0003-2300-6117)
- Zhihan Yan (ORCID: https://orcid.org/0000-0001-6826-7439)
- Kun Liu (ORCID: https://orcid.org/0000-0003-3153-9810)
- Shuang Meng (ORCID: https://orcid.org/0000-0002-1519-1247)
- Yang Yang (ORCID: https://orcid.org/0000-0002-8943-1688)
- Lu Han (ORCID: https://orcid.org/0009-0007-5911-9128)
- Shihan Cui
Institutions
- Wenzhou University (CN)
- Wenzhou Medical University (CN)
- Philips (China) (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Wenzhou-Kean University (CN)
- Wenzhou Institute of Technology Testing & Calibration (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12888-025-07432-9
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province