Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles
Ischemic heart disease (IHD) is a leading cause of mortality worldwide, primarily driven by coronary artery stenosis. Current therapies predominantly slow disease progression, with limited capacity to restore functional myocardium. Worsening metabolic disorders significantly drives heart failure. Emerging evidence suggests that stem cell therapy may improve cardiac metabolism. This review examines metabolic dysregulation in IHD and explores how stem cells and extracellular vesicles could modulate these pathways to support tissue repair.
Authors
- Yong Shi (ORCID: https://orcid.org/0000-0001-5256-1633)
- Shouting Liu
- Xinyi Zhang (ORCID: https://orcid.org/0009-0004-2973-7046)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0002-8631-8794)
- LJ Jin (ORCID: https://orcid.org/0000-0003-4305-1337)
- Junjun Xu (ORCID: https://orcid.org/0000-0001-7996-6219)
- Zheng Tu
Institutions
- Wenzhou Medical University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- npj Cardiovascular Health
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1038/s44325-025-00089-z
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province