Detection of chromosomal and gene abnormality with karyotyping, chromosomal microarray analysis and trio-based whole exome sequencing in pregnancies with fetal growth restriction: implications for precise prenatal diagnosis
Karyotyping combined with CMA remains the first-tier tool for prenatal genetic diagnosis of pregnancies with FGR, and additional trio-WES may increase the detection of chromosomal abnormality. IGF1R, GNAS, COL9A3 and FGD1 may be candidate genes causing FGR.
Authors
- Xiaohe Pan
- Meihuan Chen (ORCID: https://orcid.org/0000-0002-7356-8751)
- Meiying Cai (ORCID: https://orcid.org/0000-0002-7431-2475)
- Hailong Huang
- Shen Xu-na
- Binbin Song (ORCID: https://orcid.org/0000-0002-7093-0401)
- Yangping Chen
- Lili Zhou (ORCID: https://orcid.org/0000-0001-5044-6965)
- Xiaohe Cai
Institutions
- Fujian Medical University (CN)
- Wenzhou Central Hospital (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12884-025-08164-0
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49