Protein Aggregates in Heterozygous Alpha-1 Antitrypsin Phenotype Is a Marker for Progressive Disease
MZ individuals exhibit higher baseline liver stiffness and advanced fibrosis. The presence of PAS-D globules in liver biopsies is associated with more advanced disease and shorter transplant-free survival, highlighting the potential need for targeted therapies in this population.
Authors
- Harmeet Malhi (ORCID: https://orcid.org/0000-0002-0882-4990)
- George Marek (ORCID: https://orcid.org/0000-0002-2995-3660)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1016/j.gastha.2025.100822
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00