Associations of cholinergic white matter hyperintensity volume with cognitive decline and incident dementia in older adults: a cohort study
Cholinergic WMHV is associated with longitudinal cognitive decline and incident dementia in older adults, which might result from disruption of corpus callosum and corona radiata. These findings highlight the value of cholinergic WMHV as a potential indicator of cognitive deterioration.
Authors
- Mei Cui (ORCID: https://orcid.org/0000-0002-6449-8106)
- Kelin Xu (ORCID: https://orcid.org/0000-0002-6788-4256)
- Xingdong Chen (ORCID: https://orcid.org/0000-0003-3763-160X)
- Yanfeng Jiang (ORCID: https://orcid.org/0000-0002-5006-5190)
- Heyang Lu
- Yingzhe Wang (ORCID: https://orcid.org/0000-0002-7382-9683)
- Rui Li (ORCID: https://orcid.org/0000-0003-2318-9232)
- Jialin Li (ORCID: https://orcid.org/0000-0001-6182-1732)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Pudong Medical Center (CN)
- Huashan Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- BMC Geriatrics
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12877-025-06447-x
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Fudan University
- Huashan Hospital
- Shanghai Rising-Star Program
- National Key Research and Development Program of China