Human papillomavirus prevalence and genotype distribution among 30,147 screened women and 3,362 cervical cancer patients in China: a retrospective study
Combined TCT and HPV testing improves detection of cervical lesions compared with cytology alone. The observed age-specific and histology-specific differences in HPV prevalence and genotype distribution emphasize the need for tailored screening strategies, particularly for older women. These findings provide region-specific evidence to support the refinement of cervical cancer prevention and control strategies in China, particularly in contexts with similar demographic and epidemiological characteristics to the study population.
Authors
- Jingxue Xu (ORCID: https://orcid.org/0009-0007-2301-7648)
- Yuliang Deng (ORCID: https://orcid.org/0009-0001-0119-0016)
- Ling Sha (ORCID: https://orcid.org/0000-0002-5394-6575)
- Ye Mei (ORCID: https://orcid.org/0000-0002-3953-8508)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-1374-053X)
- Dongxia Yan
- Shupeng Zhang (ORCID: https://orcid.org/0000-0001-6478-1537)
- Wanqiu Huang (ORCID: https://orcid.org/0000-0003-3354-1148)
- Hong Xie (ORCID: https://orcid.org/0000-0002-9165-8515)
- Jianxiang Geng
- Jian Huang (ORCID: https://orcid.org/0000-0002-3153-0296)
- Yi Feng (ORCID: https://orcid.org/0000-0003-4995-1440)
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0003-3976-684X)
- Jun Luo
- Dongqin Liu
- Rong Zou
- Long Ke
Institutions
- Shanghai Jiao Tong University (CN)
- GTx (United States) (US)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Jiangsu Vocational College of Medicine (CN)
- ShenZhen People’s Hospital (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Guangxi Zhuang Autonomous Region Health and Family Planning (CN)
- Precision for Medicine (United States) (US)
- Yancheng Second People's Hospital (CN)
- Shandong First Medical University (CN)
- China National Petroleum Corporation (China) (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12985-025-02943-z
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- Fundamental Research Funds for the Central Universities
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission