Antimicrobial concentrations in the cornea and aqueous humour: a meta-analysis
We provide a practical resource for clinicians to assess whether the expected EQ1 of an antimicrobial in the cornea is above the <i>in vitro</i> MIC of the pathogen. This reduces reliance on systemic break-point concentrations. This enables standardised guidelines for evidence-based antimicrobial treatment decisions for MK.
Authors
- Timothy Neal (ORCID: https://orcid.org/0000-0002-1693-6845)
- Petya Popova
- Stephen J. Tuft (ORCID: https://orcid.org/0000-0001-8192-5192)
- Daniel M. Foulkes (ORCID: https://orcid.org/0000-0002-3892-5784)
- Gabriela Czanner (ORCID: https://orcid.org/0000-0002-1157-2093)
- Matteo Airaldi (ORCID: https://orcid.org/0000-0001-9010-1208)
- Tobi Somerville (ORCID: https://orcid.org/0000-0002-3181-7510)
- Keri McLean (ORCID: https://orcid.org/0000-0002-8907-1176)
- Stephen B. Kaye (ORCID: https://orcid.org/0000-0003-0390-0592)
- Rose Herbert (ORCID: https://orcid.org/0000-0001-6728-5125)
- G.W. Dawson
- Danielle Bernard-Deshong
- Victoria Massie
Institutions
- Slovak University of Technology in Bratislava (SK)
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- University of Southampton (GB)
- University College London (GB)
- University of Sunderland (GB)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1136/bjo-2025-327962
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00