A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues
The scID-PCR platform offers a novel and powerful approach to quantify intrahepatic HBV-positive cells with single-cell resolution. This method complements traditional serological markers offering a more nuanced view of CHB infection dynamics and supporting personalized treatment strategies.
Authors
- Taicheng Zhou (ORCID: https://orcid.org/0000-0003-0582-1150)
- Zijie Zhang (ORCID: https://orcid.org/0000-0002-2513-3091)
- Zumi Zhou
- Xin Zhang (ORCID: https://orcid.org/0000-0002-1119-9399)
- Chunmei Li (ORCID: https://orcid.org/0000-0001-8227-9719)
- Jia Wei (ORCID: https://orcid.org/0000-0001-8617-3153)
- Ran Zhao (ORCID: https://orcid.org/0000-0002-1109-5434)
- Xueyan Liu (ORCID: https://orcid.org/0000-0003-1097-1516)
- Hui Li (ORCID: https://orcid.org/0000-0002-6171-4934)
- Jingmei Li
Institutions
- Southwest University (CN)
- Yunnan University (CN)
- Yunnan Machinery Research and Design Institute (CN)
- Yunnan Yingmao Biotechnology (China) (CN)
- Yunnan Provincial Infectious Disease Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12967-025-07131-9
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yunnan University
- Yunnan Provincial Science and Technology Department