Clinical and serum risk factors for coronary restenosis in patients with coronary artery disease

Aim. To study risk factors for coronary artery restenosis in a retrospective (identification of patients with restenosis) and prospective (biomarker analysis) study. Material and methods. Patients with coronary stenosis were identified within 7 years after primary stenting. In 181 patients (67 — with coronary restenosis, 114 — without coronary restenosis), the clinical, demographic and serum biomarker profiles of patients were studied. Results. The incidence of coronary restenosis was significantly higher in men (82,1% and 69,3%, p=0,047). Propensity score matching was used to balance the groups by sex, and as a result, a higher hereditary predisposition to cardiovascular diseases (p=0,024), sinus rhythm (p=0,020), low serum apolipoprotein A1 (p=0,048) and high alanine aminotransferase (p=0,023) were shown for the restenosis group. Conclusion. Coronary artery restenosis was characterized by male sex, sinus rhythm, hereditary predisposition, increased alanine aminotransferase and decreased apolipoprotein A1.